In my neck of the woods, a 12 gauge with buckshot is the preferred medicine for "yotes".
The softer approach of human hair, etc may also work. They generally avoid humans, but the last few years the eastern coyotes in my area have become more and more brazen - I had a female friend who lived in the boonies that heard scrabbling on her deck one night, and flipped the light on, to see coyotes going through her trash.
Scared the crap outta her, lol!