I have never sent one to be graded but I do collect certified coins, I think ANACS tends to be more generous in their grading. I have seen ANACS MS68 coins that I believe other grading company's would place at a MS65 or 66. This is strictly my opinion but if you have a coin worthy of a high grade I would use NGC or PCGS. Not to mention they have better looking capsules and I believe are more widely collected.